Principal Scientist

  • Full Time
  • Randburg, Gauteng , South Africa

Mintek

Principal Scientist
AMD/2020/PSc
Advanced Materials Division

Mintek is seeking a highly skilled, detail-oriented Scientist to join the Antibody and Antigen Production Platform. This entails working with protein expression, purification, and assays to develop antibodies and antigens for diagnostic purposes. Using her/his skill set, the candidate will work with the team to manage, optimize, and run expression, purification, and assay experiments on multiple systems for validation.

JOB REQUIREMENTS:

  • Expression, purification, and characterization of antibodies and antigens
  • Assist in identifying, developing, and validating a variety of biological assays used to support the development of tool antibodies and antigens
  • Assist in the optimization of high throughput expression, purification, and assays automation systems used to support the development of therapeutic and tool antibodies
  • Characterize assays for their throughput, strengths and weaknesses and suggest improvements or alternatives to drive innovation and continual improvements
  • Work with the process owners to run day-to-day assays and to identify areas of improvement
  • Analyse and track data over time to identify systematic errors and drift
  • Strong knowledge of present and next generation antibody discovery, small scale expression, purification, and screening
  • Experience using automation systems and liquid handlers
  • Demonstrated experience with techniques used to measure antibody-antigen interaction (ie. ELISA, HTRF, AlphaScreen)
  • Knowledge of cell based assays is a plus
  • Demonstrated independence in experimental design, execution, data analysis, and troubleshooting

QUALIFICATIONS & EXPERIENCE:

  • PhD degree with 5 years relevant experience in Biochemistry, Molecular or Cell Biology, Immunology or related field
  • Leadership skills and experience of managing researchers are essential
  • Must be computer literate

BEHAVIORAL COMPETENCIES:

  • Effective communication of work, plans, and progress using written and verbal communication
  • Ability to efficiently manage and prioritize multiple projects and coordinate material exchanges with end users
  • Attention to detail with excellent organizational skills and accurate record keeping
  • Passion for planning and conducting new and innovative projects is essential.

CLOSING DATE:  08 September 2020                                     SALARY: Negotiable                              

The above-mentioned vacancy is also available on the Mintek website at www.mintek.co.za

Mintek is an equal opportunity, affirmative action employer, whose aim is to promote representivity in all levels of occupational categories.